| 货号 | 21871-1g |
| 描述 | Propafenone is an inhibitor of voltage-dependent sodium channels and a Class I antiarrhythmic drug.1 It also inhibits K+, KATP, and Ca2+ channels in cardiac cells.2,3,4 In transfected HEK293 cells, it inhibits hKCa2.3 and hKCa2.2 channels with IC50 values of 42 and 80 µM, respectively.5 Formulations containing propafenone are used to treat cardiac arrhythmia. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hashimoto, K.,Satoh, H., and Imai, S. Effects of etafenone and antiarrhythmic drugs on Na and Ca channels of guinea pig atrial muscle. J. Cardiovasc. Pharmacol. 1(5), 561-570 (1979). 2.Delpón, E.,Valenzuela, C.F.,Pérez, O., et al. Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating component. Circ. Res. 76(2), 223-235 (1995). 3.Delgado, C.,Tamargo, J.,D., H., et al. Effects of propafenone on calcium current in guinea-pig ventricular myocytes. Br. J. Pharmacol. 108(3), 721-727 (1993). 4.Christé, G.,Tebbakh, H.,Šimurdová, M., et al. Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes. Eur. J. Pharmacol. 373(2-3), 223-232 (1999). 5.Simó-Vicens, R.,Sauter, D.R.P.,Grunnet, M., et al. Effect of antiarrhythmic drugs on small conductance calcium - activated potassium channels. Eur. J. Pharmacol. (2017). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 377.9 |
| 分子式 | C21H27NO3 • HCl |
| CAS号 | 34183-22-7 |
| 稳定性 | ≥ 2 years |
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