CCT251545
货号：
18761-1mg 基本售价：
518.0 元 规格：
1 mg
产品信息
概述| 货号 | 18761-1mg |
| 描述 | CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM).1 It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19.2 Through its effects on Cdk8 and Cdk19, CCT251545 alters Wnt pathway-regulated gene expression.2 It reduces tumor growth in COLO 205 human colon cancer xenografts after oral dosing (70 mg/kg bid) and in Wnt-dependent tumors.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mallinger, A.,Crumpler, S.,Pichowicz, M., et al. Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen. J. Med. Chem. 58(4), 1717-1735 (2015).
2.Dale, T.,Clarke, P.A.,Esdar, C., et al. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nat. Chem. Biol. 11(12), 973-980 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 421.9 |
| 分子式 | C23H24ClN5O |
| CAS号 | 1661839-45-7 |
| 稳定性 | ≥ 2 years |
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