| 货号 | 18169-500ug |
| 描述 | Dynorphin A is a heptadecapeptide released from the cleavage of prodynorphin and found widely distributed in the central nervous system, where it is implicated in antinociceptive functions.1,2,3 It acts as an opioid receptor agonist with nanomolar binding affinity to the three major isotypes κ, µ, and δ (Kis = 0.5-1 nM) and has also been shown to activate human ORL1, a novel opioid receptor-like receptor (Ki = 386 nM).4 |
| 别名 | Dynorphin A (1-17); |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Berman, Y.,Juliano, L., and Devi, L.A. Specificity of the dynorphin-processing endoprotease: comparison with prohormone convertases. Journal of Neurochemistry 72, 2120-2196 (1999). 2.Janecka, A.,Fichna, J., and Janecki, T. Opioid receptors and their ligands. Current Topics in Medicinal Chemistry 4, 1-17 (2004). 3.Dhawan, B.N.,Cesselin, F.,Raghubir, R., et al. International Union of Pharmacology. XII. Classification of opioid receptors. Pharmaceutical Research 48(4), 567-592 (1996). 4.Zhang, S.,Tong, Y.,Tian, M., et al. Dynorphin A as a potential endogenous ligand for four members of the opioid receptor gene family. Journal of Pharmacology and Experimental Therapeutics 286(1), 136-141 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 2147.5 |
| 分子式 | C99H155N31O23 |
| CAS号 | 80448-90-4 |
| 稳定性 | ≥ 2 years |
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