| 货号 | 17580-5mg |
| 描述 | 6-Diazo-5-oxo-L-nor-Leucine (DON) is a glutamine analog that inhibits glutaminases (Ki = 6 µM) and other glutamine-utilizing enzymes, including cytidine triphosphate synthase (CTPS), which uses glutamine in the synthesis of CTP.1,2,3 DON is commonly used in cells or tissues but its use in whole animals is limited by its teratogenicity.3,4,5 |
| 别名 | DON;NSC 7365; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Willis, R.C., and Seegmiller, J.E. The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast. J.Cell Physiol. 93, 375-382 (1977). 2.Thangavelu, K.,Chong, Q.Y.,Low, B.C., et al. Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA). Sci.Rep. 4, 1-7 (2014). 3.Thomas, A.G.,Rojas, C.,Tanega, C., et al. Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors. Biochemical and Biophysical Research Communications 438(2), 243-248 (2013). 4.Botman, D.,Tigchelaar, W., and Van Noorden, C.J.F. Determination of phosphate-activated glutaminase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry). Journal of Histochemistry and Cytochemistry 62(11), 813-826 (2014). 5.Greene, R.M., and Kochhar, D.M. Limb development in mouse embryos: Protection against teratogenic effects of 6-diazo-5-ox-L-norleucine (DON) in vivo and in vitro. J.Embryol.Exp.Morphol. 33(2), 355-370 (1975). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 171.2 |
| 分子式 | C6H9N3O3 |
| CAS号 | 157-03-9 |
| 稳定性 | ≥ 2 years |
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