| 货号 | 14997-10g |
| 描述 | Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus.1 In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling.2,3 Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently.1 Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bailey, C.J. and Turner, R.C. Drug therapy: Metformin. New England Journal of Medicine 334(9), 574-579 (1996). 2.Kim, Y.D.,Park, K.G.,Lee, Y.S., et al. Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes 57(2), 306-314 (2008). 3.Viollet, B.,Guigas, B.,Garcia, N.S., et al. Cellular and molecular mechanisms of metformin: An overview. Clin.Sci.(Lond) 122(6), 253-270 (2012). 4.Appleyard, M.V.C.L.,Murray, K.E.,Coates, P.J., et al. Phenformin as prophylaxis and therapy in breast cancer xenografts. British Journal of Cancer 106(6), 1117-1122 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 241.7 |
| 分子式 | C10H15N5 • HCl |
| CAS号 | 834-28-6 |
| 稳定性 | ≥ 2 years |
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