ZCL 278
货号：
14849-5mg 基本售价：
518.0 元 规格：
5 mg
产品信息
概述| 货号 | 14849-5mg |
| 描述 | ZCL 278 is a cell-permeable inhibitor of Cdc42, a Rho family GTPase.1 It binds into the surface groove on Cdc42 (Kd = 6.4-11.4 µM), blocking interaction with intersectin (ITSN), a guanine nucleotide exchange factor (GEF).1 It inhibits Cdc42-mediated microspike formation and neuronal branching in 3T3 fibroblast and neonatal cortical neurons, respectively.1 ZCL 278 also exhibits potent antiviral activity by inhibiting cellular entry of Junin virus (JUNV) and other enveloped viruses into cells and inhibiting viral replication in mice.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Friesland, A.,Zhao, Y.,Chen, Y.-H., et al. Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc. Natl. Acad. Sci. USA 110(4), 1261-1266 (2016).
2.Chou, Y.-y.,Cuevas, C.,Carocci, M., et al. Identification and characterization of a novel broad-spectrum virus entry inhibitor. J. Virol. 90(9), 4494-4510 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 584.9 |
| 分子式 | C21H19BrClN5O4S2 |
| CAS号 | 587841-73-4 |
| 稳定性 | ≥ 2 years |
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