| 货号 | 11433-1mg |
| 描述 | Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi.1 It inhibits 20S proteasomal chymotrypsin activity (IC50 = 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB.2,3 Gliotoxin also induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils.4,5 It also inhibits geranylgeranyltransferase I and farnesyltransferase (IC50 = 17 and 80 μM, respectively).6 Gliotoxin potently suppresses viral infection by Nipah and Hendra virus in vitro(IC50 = 149 and 579 nM, respectively).7 While gliotoxin production by fungi correlates with invasiveness, its role in aspergillosis remains unclear.1 |
| 别名 | Aspergillin;S. N. 12870; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kwon-Chung, K.J. and Sugui, J.A. What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus? Med.Mycol. 47, S97-S103 (2009). 2.Kroll, M.,Arenzana-Seisdedos, F.,Bachelerie, F., et al. The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasome. Chemistry & Biology 6(10), 689-698 (1999). 3.Pahl, H.L.,Krauss, B.,Schulze-Osthoff, K., et al. The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-κB. Journal of Experimental Medicine 183, 1829-1840 (1996). 4.Anselmi, K.,Stolz, D.B.,Nalesnik, M., et al. Gliotoxin causes apoptosis and necrosis of rat Kupffer cells in vitro and in vivo in the absence of oxidative stress: Exacerbation by caspase and serine protease inhibition. Journal of Hepatology 47(1), 103-113 (2007). 5.Orciuolo, E.,Stanzani, M.,Canestraro, M., et al. Effects of Aspergillus fumigatus gliotoxin and methylprednisolone on human neutrophils: Implications for the pathogenesis of invasive aspergillosis. Journal of Leukocyte Biology 82(4), 839-848 (2007). 6.Vigushin, D.M.,Mirsaidi, N.,Brooke, G., et al. Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo. Med.Oncol. 21(1), 21-30 (2004). 7.Aljofan, M.,Sganga, M.L.,Lo, M.K., et al. Antiviral activity of gliotoxin, gentian violet and brilliant green against Nipah and Hendra virus in vitro. Virol.J. 6(187), (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 326.4 |
| 分子式 | C13H14N2O4S2 |
| CAS号 | 67-99-2 |
| 稳定性 | ≥ 2 years |
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