| 货号 | 11166-5mg |
| 描述 | 5-Azacytidine is an analog of cytidine which can be incorporated into DNA, inhibit DNA methyltransferases, and cause hypomethylation of cytosine residues in the absence of any significant mutagenic effects.1,2 Decitabine is a 2’-deoxy analog of 5-azacytidine which similarly causes hypomethylation of DNA by inhibiting DNA methyltransferases in a concentration-dependent manner.1,2,3 This action is useful in conditions characterized by DNA hypermethylation, as is found in myelodysplastic syndromes.4 |
| 别名 | 5-aza-2’-Deoxycytidine;DAC;Dacogen;NSC 127716; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Esteller, M. Epigenetics in cancer. N. Engl. J. Med. 358, 1148-1159 (2008). 2.Lyko, F. and Brown, R. DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J. Natl. Cancer Inst. 97(20), 1498-1506 (2005). 3.Stresemann, C.,Brueckner, B.,Musch, T., et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 66(5), 2794-2800 (2006). 4.Ornstein, M.C. and Sekeres, M.A. Combination strategies in myelodysplastic syndromes. Int. J. Hematol. 95, 26-33 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 228.2 |
| 分子式 | C8H12N4O4 |
| CAS号 | 2353-33-5 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |