CAY10649
货号：
10804-1mg 基本售价：
518.0 元 规格：
1 mg
产品信息
概述| 货号 | 10804-1mg |
| 描述 | 5-Lipoxygenase (5-LO) catalyzes the biosynthesis of leukotrienes, which are involved in a variety of inflammatory responses, including neutrophil chemotaxis, vascular permeability, and smooth muscle contraction.1 CAY10649 is a thiazolinone compound that demonstrates direct inhibition of 5-lipoxygenase (5-LO) product formation in intact polymorphonuclear leukocytes (PMNL) (IC50 = 0.28 μM) and a soluble fraction of a S100 PMNL cell lysate (IC50 = 0.09 μM) after stimulation with calcium and arachidonic acid.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Samuelsson, B.,Dahlén, S.E.,Lindgren, J.Å., et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237, 1171-1176 (1987).
2.Hofmann, B.,Barzen, S.,Rödl, C.B., et al. A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors. Journal of Medicinal Chemistry 54(6), 1943-1947 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 329.8 |
| 分子式 | C17H12ClNO2S |
| CAS号 | 1272519-89-7 |
| 稳定性 | ≥ 2 years |
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