| 货号 | 21616-500mg |
| 描述 | Levomefolate is the calcium salt of 5-methyltetrahydrofolic acid (Item No. 16159), a biologically active form of folic acid (Item No. 20515) that functions, in conjunction with Vitamin B12 (Item No. 18425), as a methyl-group donor involved in the conversion of homocysteine to methionine.1,2 The availability of methyl groups is essential for a variety of methylation reactions including the synthesis of DNA and proper neural tube closure.1 Levomefolate is included in formulations of certain oral contraceptives to ensure adequate folic acid levels in women of child-bearing age to reduce the risk of neural tube defects. The combination of levomefolate and oral contraceptives increases folic acid levels.3,4 |
| 别名 | BAY 86-7660;LMCA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Blom, H.J., and Smulders, Y. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. J.Inherit.Metab.Dis. 34(1), 75-81 (2011). 2.Zhang, X.,Li, H.,Jin, H., et al. Effects of homocysteine on endothelial nitric oxide production. American Journal of Physiology.Renal Physiology 279(4), 671-678 (2000). 3.Blode, H.,Klipping, C.,Richard, F., et al. Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone. Contraception 85(2), 177-184 (2012). 4.Bart, S., Sr.,Marr, J.,Diefenbach, K., et al. Folate status and homocysteine levels during a 24-week oral administration of a folate-containing oral contraceptive: A randomized, double-blind, active-controlled, parallel-group, US-based multicenter study. Contraception 85(1), 42-50 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 497.5 |
| 分子式 | C20H23N7O6 • Ca |
| CAS号 | 151533-22-1 |
| 稳定性 | ≥ 2 years |
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