| 货号 | 19087-1mg |
| 描述 | Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.1,2,3 HLY78 is a positive modulator of the Wnt/β-catenin pathway, as it augments Wnt-mediated signaling in cells at concentrations of 5 to 20 µM.4 It has no significant effect alone, and it does not affect LiCl-stimulated β-catenin signaling. A biotinylated form of HLY78 binds Axin at its DIX domain, which is thought to potentiate Axin-LRP6 association.4 HLY78 activates Wnt signaling in vivo, altering Wnt-dependent gene expression and embryonic development in zebrafish.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Polakis, P. Wnt signaling and cancer. Genes & Development 14, 1837-1851 (2000). 2.Reya, T., and Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 834-850 (2005). 3.Clevers, H. Wnt/β-catenin signaling in development and disease. Cell 127, 469-480 (2006). 4.Wang, S.,Yin, J.,Chen, D., et al. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nature Chemical Biology 9, 579-585 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 267.3 |
| 分子式 | C17H17NO2 |
| CAS号 | 854847-61-3 |
| 稳定性 | ≥ 2 years |
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