SW033291
货号：
18040-1mg 基本售价：
504.0 元 规格：
1 mg
产品信息
概述| 货号 | 18040-1mg |
| 描述 | The enzyme 15-hydroxy prostaglandin dehydrogenase (15-PGDH) initiates the catabolism of PGs and related eicosanoids.1,2 SW033291 is a potent inhibitor of 15-PGDH (Ki = ~0.1 nM) that has activity in vivo.3 It rapidly increases the levels of PGE2 in bone marrow and other tissues in mice after intraperitoneal injection.3 SW033291 accelerates hematopoietic recovery in mice receiving bone marrow transplant and promotes tissue regeneration in mouse models of colon and liver injury.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tai, H.H.,Ensor, C.M.,Tong, M., et al. Prostaglandin catabolizing enzymes. Prostaglandins & Other Lipid Mediators 68-69, 483-493 (2002).
2.Buczynski, M.W.,Dumlao, D.S., and Dennis, E.A. Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. Journal of Lipid Research 50, 1015-1038 (2009).
3.Zhang, Y.,Desai, A.,Yang, S.Y., et al. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science 348(6240), aaa2340-2341-aaa2340-2348 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 412.6 |
| 分子式 | C21H20N2OS3 |
| CAS号 | 459147-39-8 |
| 稳定性 | ≥ 2 years |
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