| 货号 | 17448-1mg |
| 描述 | BAZ2A/B are bromodomain-containing proteins whose biological function, while not yet confirmed, is believed to function similarly to ACF1, the Drosophila BAZ2B ortholog. ACF complexes play roles in establishing regular nucleosome spacing during chromatin assembly and influencing different remodeling outcomes at target loci.1,2 A rare allele of BAZ2B has been identified to be a predictor of Sudden Cardiac Death.3 BAZ2-ICR is a small molecule inhibitor of BAZ2A (Kd = 109 nM; IC50 = 130 nM) and BAZ2B (Kd = 170 nM; IC50 = 180 nM) bromodomains.4 It demonstrates 15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains.4 BAZ2-ICR has been shown to displace BAZ2 bromodomains in living cells by demonstrating accelerated FRAP recovery at 1 µM in the BAZ2A FRAP assay.4 See the Structural Genomics Consortium (SGC) website for more information. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Clapier, C.R., and Cairns, B.R. The biology of chromatin remodeling complexes. Annual Reviews of Biochemistry 78, 273-304 (2009). 2.He, X.,Fan, H.Y.,Garlick, J.D., et al. Diverse regulation of SNF2h chromatin remodeling by noncatalytic subunits. Biochemistry 47, 7025-7033 (2008). 3.Arking, D.E.,Junttila, M.J.,Goyette, P., et al. Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. PLoS Genetics 7(6), 1-9 (2011). 4.Drouin, L.,McGrath, S.,Vidler, L.R., et al. Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B. Journal of Medicinal Chemistry 58(5), 2553-2559 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 357.4 |
| 分子式 | C20H19N7 |
| CAS号 | 1665195-94-7 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |