PNU 282987
货号：
17424-5mg 基本售价：
504.0 元 规格：
5 mg
产品信息
概述| 货号 | 17424-5mg |
| 描述 | PNU 282987 is a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs; Ki = 26 nM for the rat receptor).1 It has negligible activity against α1β1γδ and α3β4 nAChRs as well as a panel of monoamine, muscarinic, glutamate, and GABA receptors, except 5-HT3(Ki = 930 nM).1 PNU 282987 evokes whole-cell currents from cultured rat hippocampal neurons and enhances GABAergic synaptic activity when applied to hippocampal slices.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bodnar, A.L.,Cortes-Burgos, L.A.,Cook, K.K., et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors. J. Med. Chem. 48(4), 905-908 (2005).
2.Hajós, M.,Hurst, R.S.,Hoffmann, W.E., et al. The selective α7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. J. Pharmacol. Exp. Ther. 312(3), 1213-1222 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 264.8 |
| 分子式 | C14H17ClN2O |
| CAS号 | 711085-63-1 |
| 稳定性 | ≥ 2 years |
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