RS 504393
货号：
17330-1mg 基本售价：
504.0 元 规格：
1 mg
产品信息
概述| 货号 | 17330-1mg |
| 描述 | RS 504393 is a selective antagonist of the MCP-1 receptor CCR2 (IC50s = 89 nM and >100 μM for CCR2 and CCR1, respectively).1 It has been shown to inhibit MCP-1-stimulated chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mirzadegan, T.,Diehl, F.,Ebi, B., et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: Binding to a common chemokine receptor motif within the helical bundle. The Journal of Biological Chemisty 275(33), 25562-25571 (2000).
2.Furuichi, K.,Wada, T.,Iwata, Y., et al. CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J. Am. Soc. Nephrol. 14(10), 2503-2515 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 417.5 |
| 分子式 | C25H27N3O3 |
| CAS号 | 300816-15-3 |
| 稳定性 | ≥ 2 years |
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