LEI-106
货号：
16419-1mg 基本售价：
504.0 元 规格：
1 mg
产品信息
概述| 货号 | 16419-1mg |
| 描述 | In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG; Item No. 62160) by attacking DAG at the sn-1 position. LEI-106 is a potent in vitro inhibitor of sn-1 DAGLα (IC50 = 18 nM).1 It blocks the hydrolysis of sn-1-oleoyl-2-AG, the natural substrate of DAGLα, with a Ki value of 0.7 µM.1 LEI-106 inhibits the hydrolysis of 2-AG by the monoacylglycerol lipase ABHD6 in mouse brain membrane homogenates and in HEK293T cell membrane preparations (Ki = 0.8 µM).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Janssen, F.J.,Deng, H.,Allarà, M., et al. Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase α and α/β-hydrolase domain 6. Journal of Medicinal Chemistry 57(15), 6610-6622 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 481.6 |
| 分子式 | C26H27NO6S |
| CAS号 | 1620582-23-1 |
| 稳定性 | ≥ 2 years |
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