| 货号 | 13988-50mg |
| 描述 | Mycophenolate mofetil is a prodrug for mycophenolic acid, a potent inhibitor of inosine monophosphate dehydrogenase (IC50 = 11 nM).1 Inhibition of this enzyme blocks de novo GTP generation as well as RNA and DNA synthesis in lymphocytes.2 In this way, mycophenolate mofetil inhibits lymphocyte proliferation and activation.2 This immunosuppression is used to benefit organ transplantation as well as autoimmunological diseases like lupus.2,3,4,5 |
| 别名 | Cellcept®;Linfonex;MMF;RS 61443; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Watkins, W.J.,Chen, J.M.,Cho, A., et al. Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH. Bioorganic & Medicinal Chemistry Letters 16(13), 3479-3483 (2006). 2.Yildirim-Toruner, C. and Diamond, B. Current and novel therapeutics in the treatment of systemic lupus erythematosus. J. Allergy Clin. Immunol. 127(2), 303-314 (2011). 3.Encke, J.,Uhl, W.,Stremmel, W., et al. Immunosuppression and modulation in liver transplantation. Nephrology Dialysis Transplantation 19(Suppl. 4), iv22-iv25 (2004). 4.Knoop, C.,Haverich, A. and Fischer, S. Immunosuppressive therapy after human lung transplantation. European Respiratory Journal 23, 159-171 (2004). 5.Appel, G.B. New and future therapies for lupus nephritis. Cleve. Clin. J. Med. 79(2), 134-140 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 433.5 |
| 分子式 | C23H31NO7 |
| CAS号 | 128794-94-5 |
| 稳定性 | ≥ 2 years |
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