| 货号 | 10012674-5mg |
| 描述 | Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density.1 This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.2 Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group) and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.3C18:1-Δ9cis-(L)-HSL is a long-chain AHL that may have antimicrobial activity4 and thus, might be used to inhibit pathogenesis by regulating bacerial quorum sensing signaling.5 |
| 别名 | C18:1-Δ9cis-(L)-HSL;N-(2-oxotetrahydrofuran-3S-yl) Oleyl Amide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.González, J.E. and Keshavan, N.D. Messing with bacterial quorum sensing. Microbiology and Molecular Biology Reviews 70(4), 859-875 (2006). 2.Gould, T.A.,Herman, J.,Krank, J., et al. Specificity of acyl-homoserine lactone syntheses examined by mass spectrometry. Journal of Bacteriology 188(2), 773-783 (2006). 3.Penalver, C.G.N.,Morin, D.,Cantet, F., et al. Methylobacterium extorquens AM1 produces a novel type of acyl-homoserine lactone with a double unsaturated side chain under methylotrophic growth conditions. FEBS Letters 580, 561-567 (2006). 4.Kajiyama, S.,Tawara, T. and Tamano, A. Production of homoserine lactone derivative. JP19830153621 19830823, 535-540 (1985). 5.Cegelski, L.,Marshall, G.R.,Eldridge, G.R., et al. The biology and future prospects of antivirulence therapies. Nature Reviews.Microbiology 6(1), 17-27 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 365.6 |
| 分子式 | C22H39NO3 |
| CAS号 | 1400974-23-3 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |