| 货号 | 9002014-10mg |
| 描述 | Seratrodast is a potent antagonist of the thromboxane A2(TXA2) receptor (TP), blocking specific binding of U-46619 (Item No. 16450) to guinea pig platelets with an IC50 value of 7.4 nM and platelet aggregation induced by U-44069 (Item No. 16440) with an IC50 value of 350 nM.1,2 It is metabolized, in liver microsomes, by cytochrome P450 (CYP) isoforms 3A and 2C9/10, with a minor contribution from CYP2C8 and CYP2C19.3 Seratrodast is commonly used to study the roles of the TP receptor in animal airways and in tissue samples.1,4,5,6 |
| 别名 | AA2414;A-73001;ABT-001; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Imura, Y.,Terashita, Z.,Shibouta, Y., et al. Antagonistic action of AA-2414 on thromboxane A2/prostaglandin endoperoxide receptor in platelets and blood vessels. Japanese Journal of Pharmacology 52(1), 35-53 (1990). 2.Shiraishi, M.,Kato, K.,Terao, S., et al. Quinones. 4. Novel eicosanoid antagonists: Synthesis and pharmacological evaluation. Journal of Medicinal Chemistry 32(9), 2214-2221 (1989). 3.Kumar, G.N.,Dubberke, E.,Rodrigues, A.D., et al. Identification of cytochromes P450 involved in the human liver microsomal metabolism of the thromboxane A2 inhibitor seratrodast (ABT-001). Drug Metabolism and Disposition 25(1), 110-115 (1997). 4.Miyagawa, N.,Iwasaki, H.,Kato, T., et al. Two pharmacological phases in antigen-induced immediate airway response in rats. Biological and Pharmaceutical Bullentin 32(12), 2260-2264 (2008). 5.Nawa, H.,Kurosaki, Y., and Kawasaki, H. Different prostanoids are involved in bradykinin-induced endothelium-dependent and -independent vasoconstriction in rat mesenteric resistance arteries. Journal of Pharmacological Sciences 94(2), 115-121 (2004). 6.Jin, X.,Satoh-Otonashi, Y.,Zamami, Y., et al. Age-related disappearance of the inhibitory effect of vascular endothelium on agonist-induced vasoconstriction in rat mesenteric vascular beds. Journal of Pharmacological Sciences 111(4), 372-380 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 354.4 |
| 分子式 | C22H26O4 |
| CAS号 | 112665-43-7 |
| 稳定性 | ≥ 2 years |
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