Saquinavir (mesylate)
货号：
9001893-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 9001893-5mg |
| 描述 | Saquinavir is an HIV protease inhibitor (Kis = 0.12 and < 0.1 nM for HIV-1 and HIV-2 protease, respectively) that exhibits antiviral activity with low cytotoxicity.1,2 When co-administered with 50 mg/kg ritonavir (Item No. 13872), the bioavailability of 20 mg/kg saquinavir has been shown to increase 325-fold in mice through a mechanism that inhibits its metabolism by CYP3A.3 |
| 别名 | Invirase®;Ro 31-8959/003; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Roberts, N.A.,Martin, J.A.,Kinchington, D., et al. Rational design of peptide-based HIV proteinase inhibitors. Science 248(4953), 358-361 (1990).
2.Tucker, T.J.,Lumma, W.C., Jr.,Payne, L.S., et al. A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: Synthesis, enzyme inhibition, and antiviral activity. Journal of Medicinal Chemistry 35(14), 2525-2533 (1992).
3.Tomaru, A.,Takeda-Morishita, M.,Banba, H., et al. Analysis of the pharmacokinetic boosting effects of ritonavir on oral bioavailability of drugs in mice. Drug Metab.Pharmacokinet. 28(2), 144-152 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 767 |
| 分子式 | C38H50N6O5 • CH3SO3H |
| CAS号 | 149845-06-7 |
| 稳定性 | ≥ 2 years |
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