A 83-01
货号：
9001799-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 9001799-1mg |
| 描述 | A 83-01 is an inhibitor of TGF-β type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively).1 It blocks the phosphorylation of Smad2/3 and inhibits TGF-β-induced epithelial-to-mesenchymal transition.1 It has little effect on bone morphogenic type I receptors, p38 mitogen-activated protein kinase, or ERK.1 A 83-01 has been used to reprogram fibroblasts into alternative lineages, including neural stem cells and cardiomyocytes.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tojo, M.,Hamashima, Y.,Hanyu, A., et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Cancer Science 96(11), 791-800 (2005).
2.Cao, N.,Huang, Y.,Zheng, J., et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352(6290), 1216-1220 (2016).
3.Zhang, M.,Lin, Y.H.,Sun, Y.J., et al. Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell Apr, (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 421.5 |
| 分子式 | C25H19N5S |
| CAS号 | 909910-43-6 |
| 稳定性 | ≥ 2 years |
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