| 货号 | 9001348-1mg |
| 描述 | Resibufogenin is a cardiac glycoside first isolated from Bufonis venom that acts as an inhibitor of the Na+/K+-ATPase.1 It exhibits cardiotonic, vasopressor, and respiratory stimulating actions in both animal and clinical models.2 Resibufogenin has been used to antagonize the action of marinobufagenin in a rat experimental model of preeclampsia.3 Resibufogenin is also reported to have antiproliferative effects against cancer cells, inducing cell cycle arrest by suppressing the expression of cyclin D1.4 |
| 别名 | Bufogenin;NSC 90783;Respigon; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pamnani, M.B.,Chen, S.,Bryant, H.J., et al. Effects of three sodium-potassium adenosine triphosphatase inhibitors. Hypertension 18(3), 316-324 (1991). 2.Iwatsuki, K.,Yusa, T.,Kataoka, Y., et al. Experimental and clinical studies of resibufogenin. Tohoku J. Exp. Med. 86(2), 93-101 (1965). 3.Puschett, J.B.,Agunanne, E., and Uddin, M.N. Marinobufagenin, resibufogenin and preeclampsia. Biochim Biophys.Acta. 1802(12), 1246-1253 (2010). 4.Ichikawa, M.,Sowa, Y.,Iizumi, Y., et al. Resibufogenin induces G1-phase arrest through the proteasomal degradation of cyclin D1 in human malignant tumor cells. PLoS One 10(6), (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 384.5 |
| 分子式 | C24H32O4 |
| CAS号 | 465-39-4 |
| 稳定性 | ≥ 2 years |
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