Tiplaxtinin
货号：
9000450-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 9000450-1mg |
| 描述 | Tiplaxtinin is an inhibitor of plasminogen activator 1 (PAI-1; IC50 = 2.7 µM with human recombinant PAI-1).1 In rat thrombosis models, the time to occlusion is longer, carotid blood flow reduction is partially prevented, and thrombus size is smaller compared with control rats.1,2 |
| 别名 | PAI-039;Tiplasinin; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Elokdah, H.,Abou-Gharbia, M.,Hennan, J.K., et al. Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: Design, synthesis, and preclinical characterization. J. Med. Chem. 47(14), 3491-3494 (2004).
2.Hennan, J.K.,Morgan, G.A.,Swillo, R.E., et al. Effect of tiplaxtinin (PAI-039), an orally bioavailable PAI-1 antagonist, in a rat model of thrombosis. J. Thromb. Haemost. 6(9), 1558-1564 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 439.4 |
| 分子式 | C24H16F3NO4 |
| CAS号 | 393105-53-8 |
| 稳定性 | ≥ 2 years |
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