ACPT-II
货号：
78020-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 78020-1mg |
| 描述 | ACPT-II is a general competitive antagonist of metabotropic glutamate (mGlu) receptors. The KB values for mGlu1a, mGlu2, and mGlu4a receptors are 115, 88, and 77 µM, respectively.1 It binds to the large extracellular domain called a Venus flytrap module, where agonists bind.2 ACPT-II is a stereoisomer of the group III mGlu receptor-selective antagonist, ACPT-I.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Acher, F.C.,Tellier, F.J.,Azerad, R., et al. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: New tools to discriminate between metabotropic glutamate receptor subtypes. Journal of Medicinal Chemistry 40, 3119-3129 (1997).
2.Bessis, A.S.,Ronard, P.,Gaven, F., et al. Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proceedings of the National Academy of Sciences of the United States of America 99(17), 11097-11102 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 217.2 |
| 分子式 | C8H11NO6 |
| CAS号 | 195209-04-2 |
| 稳定性 | ≥ 2 years |
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