| 货号 | 60972-100ug |
| 描述 | The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals.1,2D-myo-Inositol-1,3,4-triphosphate (Ins(1,3,4)-P3) is one of several different inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels.3 The levels of Ins(1,3,4)-P3 are in turn regulated by the levels of cytosolic free calcium.4 The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P3 which releases calcium from intracellular storage reservoirs, leading to a dramatic but transient increase in the cytosolic concentration of free calcium.5 |
| 别名 | Ins(1,3,4)-P3 (sodium salt);1,3,4-IP3 (sodium salt); |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361, 315-325 (1993). 2.Majerus, P.W. Inositol phosphate biochemistry. Annual Reviews of Biochemistry 61, 225-250 (1992). 3.Yang, X.,Rudolf, M.,Carew, M.A., et al. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. The Journal of Biological Chemisty 274, 18973-18980 (1999). 4.Lew, P.D.,Monod, A.,Krause, K.H., et al. The role of cytosolic free calcium in the generation of inositol 1,4,5-triphosphate and inositol 1,3,4-triphosphate in HL-60 cells. The Journal of Biological Chemisty 261, 13121-13127 (1986). 5.Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Japanese Journal of Pharmacology 74, 125-137 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 486 |
| 分子式 | C6H12O15P3 • 3Na |
| 稳定性 | ≥ 2 years |
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