| 货号 | 21806-1mg |
| 描述 | UBP 310 is an antagonist of ionotropic glutamate receptor 5 (GluR5 or GluK1; Kd = 130 nM).1,2,3 It less potently binds GluR2 (GluA2) and GluR6 (GluK2; Kds = 106 and 1,626 µM, respectively).4,2 UBP 310 is inactive at metabotropic GluR group I and NMDA receptors. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Atlason, P.T.,Scholefield, C.L.,Eaves, R.J., et al. Mapping the ligand binding sites of kainate receptors: Molecular determinants of subunit-selective binding of the antagonist 3HUBP310. Mol. Pharmacol. 78(6), 1036-1045 (2010). 2.Mayer, M.L.,Ghosal, A.,Dolman, N.P., et al. Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists. J. Neurosci. 26(11), 2852-2861 (2006). 3.Perrais, D.,Pinheiro, P.S.,Jane, D.E., et al. Antagonism of recombinant and native GluK3-containing kainate receptors. Neuropharmacology 56(1), 131-140 (2009). 4.Du, M.,Rambhadran, A., and Jayaraman, V. Luminescence resonance energy transfer investigation of conformational changes in the ligand binding domain of a kainate receptor. J. Biol. Chem. 283(40), 27074-27078 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 353.4 |
| 分子式 | C14H15N3O6S |
| CAS号 | 902464-46-4 |
| 稳定性 | ≥ 2 years |
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