| 货号 | 21684-50mg |
| 描述 | Chlorin e6 (Ce6) is a second-generation photosensitizer with antitumor activity when used in conjunction with irradiation. In a mouse model of implanted fibrosarcoma, Ce6 (2.5-10 mg/kg, i.v. with irradiation at 50-200 J/cm2) led to complete tumor loss following varying levels of irradiation.1 A formulation including Ce6 was tested in a Phase I clinical study for patients with bronchogenic early superficial squamous cell carcinoma with positive results (40 mg/m2, i.v. with laser irradiation at 100 J/cm2).2 The same dosing paradigm in a Phase II clinical trial for early stage lung cancer patients led to a complete response in 82.9% of patients.3 Ce6 has been examined as a nanotechnology drug delivery tool.4 |
| 别名 | Ce6; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Katsumi, T.A.,Aizawa, K.,Kuroiwa, Y., et al. Photodynamic therapy with a diode laser for implanted fibrosarcoma in mice employing mono-L-aspartyl chlorin E6. Photochem. Photobiol. 64(4), 671-675 (1996). 2.Furukawa, K.,Okunaka, T., and Tsuchida, T. A phase I clinical study of photodynamic therapy for early stage lung carcinoma using ME2906 and a diode laser system. Porphyrins. 7, 199-206 (1998). 3.Kato, H.,Furukawa, K.,Sato, M., et al. Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung. Lung Cancer 42(1), 103-111 (2003). 4.Chai, S.,Guo, Y.,Zhang, Z., et al. Cyclodextrin-gated mesoporous silica nanoparticles as drug carriers for red light-induced drug release. Nanotechnology 28(14), 145101 (2017). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 596.7 |
| 分子式 | C34H36N4O6 |
| CAS号 | 19660-77-6 |
| 稳定性 | ≥ 2 years |
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