| 货号 | 21553-1mg |
| 描述 | DAMGO is a selective peptide agonist of the µ-opioid receptor (Kis = 1.18, 1,430, and 213 nM for human µ-, δ-, and κ-opioid receptors, respectively).1,2 DAMGO displays higher efficacy than morphine (Item No. ISO60147) for µ-opioid-induced nociception in rats.3,4 |
| 别名 | [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin;DAGO;NIH 10891;RX-783006; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hirning, L.D.,Mosberg, H.I.,Hurst, R., et al. Studies in vitro with ICI 174,864, [D-Pen2, D-Pen5]-enkephalin (DPDPE) and [D-Ala2, NMePhe4, Gly-ol]-enkephalin (DAGO). Neuropeptides 5(4-6), 383-386 (1985). 2.Zhao, G.-M.,Qian, X.,Schiller, P.W., et al. Comparison of [Dmt1]DALDA and DAMGO in binding and G protein activation at μ, δ, and κ opioid receptors. J. Pharmacol. Exp. Ther. 307(3), 947-954 (2003). 3.Fang, F.G.,Haws, C.M.,Drasner, K., et al. Opioid peptides (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: Comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medulla. Brain Res. 501(1), 116-128 (1989). 4.Kelly, E. Efficacy and ligand bias at the μ-opioid receptor. Br. J. Pharmacol. 169(7), 1430-1446 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 513.6 |
| 分子式 | C26H35N5O6 |
| CAS号 | 78123-71-4 |
| 稳定性 | ≥ 2 years |
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