RG7388
货号：
21532-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 21532-1mg |
| 描述 | RG7388 is a non-imidazoline, selective MDM2 inhibitor that blocks the binding of MDM2 to p53 (IC50 = 30 nM).1 By inhibiting MDM2, RG7388 activates the p53 pathway in SJSA1 osteosarcoma cells and inhibits the growth of xenografts in nude mice.1,2 RG7388 is orally available and prolonged daily administration results in loss of MDM2 and p21 protein, growth inhibition, and apoptosis in SJSA1 xenograft tumors.2 Like other MDM2 inhibitors, RG7388 competitively inhibits multi-drug resistance protein 1 (MRP1) and reverse MRP1-mediated multidrug resistance in cancer cells in a p53-independent manner.3 |
| 别名 | Idasanutlin;Ro 5503781; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ding, Q.,Zhang, Z.,Liu, J.J., et al. Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development. J. Med. Chem. 56(14), 5979-5983 (2013).
2.Higgins, B.,Glenn, K.,Walz, A., et al. Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approach. Clin. Cancer Res. 20(14), 3742-3752 (2014).
3.Chen, L.,Zhao, Y.,Halliday, G.C., et al. Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma. Br. J. Cancer 111(4), 716-725 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 616.5 |
| 分子式 | C31H29Cl2F2N3O4 |
| CAS号 | 1229705-06-9 |
| 稳定性 | ≥ 2 years |
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