| 货号 | 21408-5mg |
| 描述 | (R,S)-CHPG is a potent and selective agonist at metabotropic glutamate receptor 5 (mGluR5). In CHO cells, it had an EC50 of 750 µM for calcium mobilization in mGluR5a-expressing cells but was inactive in mGluR1a-expressing cells.1 In transfected HEK293 cells, (R,S)-CHPG bound mGluR1a and mGluR5a (Kis = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors.2 It reduced oxidative stress and inflammatory markers in cultured BV-2 microglial cells.3 In mouse models of traumatic brain injury, it reduced lesion volume, improved sensorimotor deficits in the beam walk test, and improved spatial memory in the Morris water maze.4 |
| 别名 | Chlorohydroxyphenylglycine;CHPG; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Doherty, A.J.,Palmer, M.J.,Henley, J.M., et al. (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 36(2), 265-267 (1997). 2.Mutel, V.,Ellis, G.J.,Adam, G., et al. Characterization of [3H]quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. Journal of Neurochemistry 75(6), 2590-2601 (2000). 3.Qiu, J.-L.,Zhu, W.-L.,Lu, Y.-J., et al. The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 85-86, 46-52 (2015). 4.Loane, D.J.,Stoica, B.A.,Byrnes, K.R., et al. Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury. J. Neurotrauma 30(5), 403-412 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 201.6 |
| 分子式 | C8H8ClNO3 |
| CAS号 | 170846-74-9 |
| 稳定性 | ≥ 1 year |
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