Alcaftadine
货号：
21290-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 21290-5mg |
| 描述 | Alcaftadine is a potent antagonist of the H1 histamine receptor (IC50 = 8.6 nM) with lower affinities for the H2 and H4 receptors (IC50s = 62 nM and 4.4 μM, respectively).1 This antiallergenic agent has anti-inflammatory and mast cell stabilizing effects.2 Alcaftadine has been shown to reduce edema and erythema in a guinea pig model of allergic conjunctivitis (ED50 = 0.1 mg/kg) more effectively than ketotifen (Item No. 20303) (ED50 = 1.0 mg/kg) and has been used in clinical formulations in eye drops for treatment of ocular itching associated with allergic conjunctivitis.1,3 Alcaftadine also binds to 5-HT2A and 5-HT2C receptors (Kis = 2.5 and 1.5 μM, respectively).1 |
| 别名 | R-89674; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gallois-Bernos, A.C. and Thurmond, R.L. Alcaftadine, a new antihistamine with combined antagonist activity at histamine H1, H2, and H4 receptors. J. Receptor Ligand Channel Res. 5, 9-20 (2012).
2.Ackerman, S.,Smith, L.M. and Gomes, P.J. Ocular itch associated with allergic conjunctivitis: Latest evidence and clinical management. Ther. Adv. Chronic Dis. 7(1), 52-67 (2016).
3.Mahvan, T.D.,Buckley, W.A. and Hornecker, J.R. Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann. Pharmacother. 46, 1025-1032 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 307.4 |
| 分子式 | C19H21N3O |
| CAS号 | 147084-10-4 |
| 稳定性 | ≥ 2 years |
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