| 货号 | 21222-10mg |
| 描述 | TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 µM).1 It blocks taxol-induced assembly of tubulin (IC50 = 6 µM) and blocks colchicine (Item No. 9000760) binding to tubulin.1 Like colchicine, TN-16 inhibits alkylation of tubulin.2 TN-16 induces metaphase arrest in renal cell carcinoma cells.3 TN-16 can be used in combination with other inhibitors to enhance the efficiency of human artificial chromosome transfer to recipient cells.4 |
| 别名 | NSC 239274; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Arai, T. Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug. FEBS Lett. 155(2), 273-276 (1983). 2.Roach, M.C. and Luduena, R.F. The effect of TN-16 on the alkylation of tubulin. Biochem. Biophys. Res. Commun. 129(1), 200-205 (1985). 3.Nakamura, M.,Kanda, S.,Kawamura, M., et al. Effects of low concentration of vinblastine on the anchorage-independent growth and in vitro invasion of human renal carcinoma cell lines. Cancer Lett. 69(2), 85-91 (1993). 4.Liskovykh, M.,Lee, N.C.O.,Larinov, V., et al. Moving toward a higher efficiency of microcell-mediated chromosome transfer. Mol. Ther. Methods Clin. Dev. 3, 16043 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 306.4 |
| 分子式 | C19H18N2O2 |
| CAS号 | 33016-12-5 |
| 稳定性 | ≥ 2 years |
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