BMS-5
货号：
21072-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 21072-1mg |
| 描述 | BMS-5 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 with IC50 values of 7 and 8 nM, respectively.1 LIMK1 and LIMK2 participate in signal pathways affecting actin dynamics by deactivating cofilin.2,3 This compound can be used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin. |
| 别名 | LIM Kinase Inhibitor I;LIMKi 3; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ross-Macdonald, P.,de Silva, H.,Guo, Q., et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol. Cancer Ther. 7(11), 3490-3498 (2008).
2.Li, X.,Zhu, Y.,Cao, Y., et al. LIM kinase activity is required for microtubule organising centre positioning in mouse oocyte meiosis. Reprod. Fertil. Dev. (2016).
3.Romarowski, A.,Battistone, M.A.,La Spina, F.A., et al. PKA-dependent phosphorylation of LIMK1 and Cofilin is essential for mouse sperm acrosomal exocytosis. Dev. Biol. 405(2), 237-249 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 431.3 |
| 分子式 | C17H14Cl2F2N4OS |
| CAS号 | 1338247-35-0 |
| 稳定性 | ≥ 2 years |
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