| 货号 | 21037-5mg |
| 描述 | RS-1 is an activator of DNA repair protein RAD51 (Kd = 48-107 for human RAD51 with different cofactors present).1 It stimulates homologous strand assimilation activity at least 5- to 11-old, enhancing homologous recombination activity of hRAD51.1 RS-1 is a potent enhancer of CRISPR-mediated genome editing, increasing homology directed repair 3- to 6-fold.2 It is used to increase CRISPR-mediated knock-in efficiencies in vitroandin vivo.3,2,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jayathilaka, K.,Sheridan, S.D.,Bold, T.D., et al. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc. Natl. Acad. Sci. USA 105(41), 15848-15853 (2008). 2.Pinder, J.,Salsman, J. and Dellaire, G. Nuclear domain knock-in screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing. Nucleic Acids Res. 43(19), 9379-9392 (2015). 3.Pan, Y.,SHen, N.,Jung-Klawitter, S., et al. CRISPR RNA-guided FokI nucleases repair a PAH variant in a phenylketonuria model. Sci. Rep. 6, 65794 (2016). 4.Song, J.,Yang, D.,Xu, J., et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat. Commun. 7, 10548 (2016). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 524.2 |
| 分子式 | C20H16Br2N2O3S |
| CAS号 | 312756-74-4 |
| 稳定性 | ≥ 2 years |
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