| 货号 | 20930-25mg |
| 描述 | 3,4,7-Trihydroxyisoflavone is a natural isoflavonoid that has antioxidant activity.1 It can be produced by the metabolism of daidzein (Item No. 10005166) or daidzin (Item No. 13202).2,3 3,4,7-Trihydroxyisoflavone inhibits several signaling pathways in cells, including tyrosinase-mediated melanin formation (IC50 = 5.2 µM), casein kinase II-mediated phosphorylation of 60S acidic ribosomal P proteins, and cyclin-dependent, kinase-regulated cell proliferation.4,5,6 |
| 别名 | 3-hydroxy Daidzein;3’,4’,7-THIF; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Komiyama, K.,Funayama, S.,Anraku, Y., et al. Isolation of isoflavonoids possessing antioxidant activity from the fermentation broth of Streptomyces sp. J. Antibiot. (Tokyo) 42(9), 1344-1349 (1989). 2.Choi, K.-Y.,Kim, T.-j.,Koh, S.-K., et al. A-ring ortho-specific monohydroxylation of daidzein by cytochrome P450s of Nocardia farcinica IFM10152. Biotechnol. J. 4(11), 1586-1595 (2009). 3.Yasuda, T. and Ohsawa, K. Urinary metabolites of daidzin orally administered in rats. Biol. Pharm. Bull. 21(9), 953-957 (1998). 4.Park, J.-S.,Kim, D.H.,Lee, J.K., et al. Natural ortho-dihydroxyisoflavone derivatives from aged Korean fermented soybean paste as potent tyrosinase and melanin formation inhibitors. Bioorg. Med. Chem. Lett. 20(3), 1162-1164 (2010). 5.Maekawa, T.,Kosuge, S.,Sakamoto, S., et al. Biochemical characterization of 60S acidic ribosomal P proteins associated with CK-II from bamboo shoots and potent inhibitors of their phosphorylation in vitro. Biol. Pharm. Bull. 22(7), 667-673 (1999). 6.Lee, D.E.,Lee, K.Q.,Song, N.R., et al. 7,3,4-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase. J. Biol. Chem. 285(28), 21458-21466 (2010). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 270.2 |
| 分子式 | C15H10O5 |
| CAS号 | 485-63-2 |
| 稳定性 | ≥ 2 years |
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