| 货号 | 20848-1mg |
| 描述 | Chenodeoxycholic acid-d4(CDCA-d4) is intended for use as an internal standard for the quantification of CDCA (Item No. 10011286) by GC- or LC-MS. CDCA is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism.1,2EC50 concentrations for activation of FXR range from 13-34 μM.3,4 In cells, CDCA also binds to bile acid binding proteins (BABP) with a reported stoichiometry of 1:2.2 CDCA toxicity is linked to increased cellular glutathione levels and increased oxidative stress. Exposure of cells to excess CDCA contributes to liver and intestinal cancers.1 |
| 别名 | Anthropodeoxycholic Acid-d4;CDCA-d4;Fluibil-d4;Hekbilin-d4;Kebilis-d4;Ulmenide-d4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tan, K.P.,Yang, M. and Ito, S. Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stress. Molecular Pharmacology 72(5), 1380-1390 (2007). 2.Eliseo, T.,Ragona, L.,Catalano, M., et al. Structural and dynamic determinants of ligand binding in the ternary complex of chicken liver bile acid binding protein with two bile salts revealed by NMR. Biochemistry 46(44), 12557-12567 (2007). 3.Urizar, N.L.,Liverman, A.B.,Dodds, D.T., et al. A natural product that lowers cholesterol as an anatagonist ligand for FXR. Science 296, 1703-1706 (2002). 4.Glickman, J.F.,Wu, X.,Mercuri, R., et al. A comparison of ALPHAScreen, TR-FRET, and TRF as assay methods for FXR nuclear receptors. Journal of Biomolecular Screening 7(1), 3-10 (2002). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 396.6 |
| 分子式 | C24H36D4O4 |
| CAS号 | 99102-69-9 |
| 稳定性 | ≥ 2 years |
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