Cyclocreatine
货号：
20649-500mg 基本售价：
490.0 元 规格：
500 mg
产品信息
概述| 货号 | 20649-500mg |
| 描述 | Cyclocreatine is a planar creatine analog that can passively transit across membranes, including the blood brain barrier, and is phosphorylated and dephosphoryated by mitochondrial and cytosolic creatine kinase.1,2 Cyclocreatine can function as a phosphagen in mouse brain in vivo and has been used to reverse cognitive deficits in Slc6a8-/y mice that lack a functional creatine transporter.3 |
| 别名 | AM 285;1-Carboxymethyl-2-iminoimidazolidine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.McLaughlin, A.C. and Cohn, M. Specificity of creatine kinase for guanidino substrates. Kinetic and proton nuclear magnetic relaxation rate studies. J. Biol. Chem. 247(13), 4382-4388 (1972).
2.Boehm, E.A.,Radda, G.K.,Tomlin, H., et al. The utilisation of creatine and its analogues by cytosolic and mitochondrial creatine kinase. Biochim. Biophys. Acta 1274(3), 119-128 (1996).
3.Kurosawa, Y.,DeGrauw, T.J.,Lindquist, D.M., et al. Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency. J. Clin. Invest. 122(8), 2837-2846 (2012).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 143.1 |
| 分子式 | C5H9N3O2 |
| CAS号 | 35404-50-3 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
