5-Ethynyl-2-deoxyuridine
货号：
20518-50mg 基本售价：
490.0 元 规格：
50 mg
产品信息
概述| 货号 | 20518-50mg |
| 描述 | 5-Ethynyl-2-deoxyuridine (EdU) is a nucleoside analog of thymidine that is used to monitor de novo DNA synthesis through click chemistry.1,2 Like 5-bromo-2’-deoxyuridine (BrdU; Item No. 15580), EdU is incorporated into DNA during active DNA synthesis. It can then be detected using a fluorescent azide probe and copper catalysis using 1,3-dipolar cycloaddition.2 Modified nucleosides, including EdU, can be cytotoxic when added to cells for prolonged periods.3 |
| 别名 | 5-EdU;EdU;2-deoxy-5-Ethynyluridine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Buck, S.B.,Bradford, J.,Gee, K.R., et al. Detection of S-phase cell cycle progression using 5-ethynyl-2-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2-deoxyuridine antibodies. Biotechniques 44, 924-929 (2008).
2.Cavanagh, B.L.,Walker, T.,Norazit, A., et al. Thymidine analogues for tracking DNA synthesis. Molecules 16, 7980-7993 (2011).
3.Meneni, S.,Ott, I.,Sergeant, C.D., et al. 5-Alkynyl-2-deoxyuridines: Chromatography-free synthesis and cytotoxicity evaluation against human breast cancer cells. Bioorg. Med. Chem. 15(8), 3082-3088 (2007).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 252.2 |
| 分子式 | C11H12N2O5 |
| CAS号 | 61135-33-9 |
| 稳定性 | ≥ 2 years |
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