| 货号 | 20343-5mg |
| 描述 | NS 1643 is an activator of the human ether-a-go-go related gene (ERG1, KCNH2, hERG) KV11.1 channel (EC50 = 10.5 μM).1,2 It also activates the KV11.2 (ERG2, KCNH6) channel, but evokes a distinctly different response from that of KV11.1.3 NS 1643 is commonly used in cells or isolated tissues.1,2,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Casis, O.,Olesen, S.-P., and Sangunietti, M.C. Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Mol. Pharmacol. 69(2), 658-665 (2006). 2.Hansen, R.S.,Diness, T.G.,Christ, T., et al. Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol. Pharmacol. 69(1), 266-277 (2006). 3.Elmedyb, P.,Olesen, S.-P., and Grunnet, M. Activation of ERG2 potassium channels by the diphenylurea NS1643. Neuropharmacology 53(2), 283-294 (2007). 4.Killeen, M.J.,Thomas, G.,Olesen, S.-P., et al. Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart. Acta. Physiol. (Oxf) 193(1), 25-36 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 380.2 |
| 分子式 | C15H10F6N2O3 |
| CAS号 | 448895-37-2 |
| 稳定性 | ≥ 2 years |
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