PH-797804
货号：
20244-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 20244-1mg |
| 描述 | PH-797804 is an inhibitor of p38α MAPK with an IC50 value of 26 nM in a cell-free assay.1,2 It is 4-fold more selective for p38α compared to p38β and does not inhibit JNK2 or ERK at concentrations up to 1 µM.1 PH-797804 treatment for 10 days in vivo demonstrates anti-inflammatory activity in chronic inflammatory disease models, significantly reducing both joint inflammation and associated bone loss in streptococcal cell wall-induced arthritis in rats and collagen-induced arthritis in mice.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hope, H.R.,Anderson, G.D.,Burnette, B.L., et al. Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J.Pharmacol.Exp.Ther. 331(3), 882-895 (2009).
2.Goldstein, D.M.,Kuglstatter, A.,Lou, Y., et al. Selective p38α inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. Journal of Medicinal Chemistry 53, 2345-2353 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 477.3 |
| 分子式 | C22H19BrF2N2O3 |
| CAS号 | 586379-66-0 |
| 稳定性 | ≥ 2 years |
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