| 货号 | 20065-5mg |
| 描述 | N-Oleoyl valine is an endogenous N-acyl amine that acts as an antagonist at the transient receptor potential vanilloid type 3 (TRPV3) receptor, which is involved in thermoregulation.1,2 N-Oleoyl valine is increased in mice following cold exposure for up to at least 16 days.3 Acute lung injury in mice increases the concentration of N-Oleoyl valine in lung tissue.4 N-acyl amines also promote mitochondrial uncoupling.3 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Raboune, S.,Stuart, J.M.,Leishman, E., et al. Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation. Front. Cell. Neurosci. 8(195), 1-11 (2014). 2.Broad, L.M.,Mogg, A.J.,Eberle, E., et al. TRPV3 in drug development. Pharmaceuticals 9(3), E55 (2016). 3.Long, J.Z.,Svensson, K.J.,Bateman, L.A., et al. The secreted enzyme PM20D1 regulates lipidated amino acid uncouplers of mitochondria. Cell 166, 1-12 (2016). 4.Balakrishna, S.,Song, W.,Achanta, S., et al. TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 307(2), L158-L172 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 381.6 |
| 分子式 | C23H43NO3 |
| CAS号 | 60374-41-6 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |