SHP099
货号：
20000-500ug 基本售价：
490.0 元 规格：
500 ug
产品信息
概述| 货号 | 20000-500ug |
| 描述 | SHP099 is an orally bioavailable inhibitor of SHP2, a non-receptor protein tyrosine phosphatase (IC50 = 71 nM).1,2 It stabilizes SHP2 in an auto-inhibited conformation.2 SHP099 suppresses signaling through the Ras-ERK pathway and blocks the proliferation of receptor tyrosine kinase-driven human cancer cells in vitroandin vivo.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Garcia Fortanet, J.,Chen, C.H.-T.,Chen, Y.-N.P., et al. Allosteric inhibition of SHP2: Identification of a potent, selective, and orally efficacious phosphatase inhibitor. J. Med. Chem. 59(17), 7773-7782 (2016).
2.Chen, Y.-N.P.,LaMarche, M.J.,Chan, H.M., et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature 535(7610), 148-152 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 352.3 |
| 分子式 | C16H19Cl2N5 |
| CAS号 | 1801747-42-1 |
| 稳定性 | ≥ 2 years |
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