SJ 172550
货号：
19999-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 19999-1mg |
| 描述 | SJ 172550 is an inhibitor of MDMX that disrupts MDMX-p53 peptide interaction with an EC50 value of 4.3 µM.1 It forms a covalent, but reversible, cysteine adduct in the MDMX p53-binding domain, locking MDMX into a conformation that prevents binding to p53.2 SJ 172550 induces apoptosis, increases p53 target gene expression, and causes p53-dependent cell death in retinoblastoma cells.1 |
| 别名 | MDMX Inhibitor II; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Reed, D.J.,Shen, Y.,Shelat, A.A., et al. Identification and characterization of the first small molecule inhibitor of MDMX. J. Biol. Chem. 285(4), 10786-10796 (2010).
2.Bista, M.,Smithson, D.,Pecak, A., et al. On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. PLoS One 7(6), e37518 (2012).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 428.9 |
| 分子式 | C22H21ClN2O5 |
| CAS号 | 431979-47-4 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
