LJI308
货号：
19924-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 19924-1mg |
| 描述 | LJI308 is a selective and potent inhibitor of the p90 ribosomal S6 kinase (RSK) family with IC50 values ranging from 4 to 13 μM for RSK isoforms 1-3.1,2 In a panel of 442 kinases, LJI308 is selective for RSK1, RSK3, and RSK4. It also inhibits S6K1, MEK4, and HIP in the low micromolar range but had no effect on other kinases tested.1 LJI308 also reduces phosphorylation of Y-box-binding protein (YB1) in MDA-MB-231 cells bearing activating mutations in the MAPK signaling pathway (EC50 = 0.21 μM) and reduces H358 growth in soft agar and colony forming assays. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Aronchik, I.,Appleton, B.A.,Basham, S.E., et al. Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol. Cancer Res. 12(5), 803-812 (2014).
2.Jain, R.,Mathur, M.,Lan, J., et al. Discovery of potent and selective RSK inhibitors as biological probes. J. Med. Chem. 58(17), 6766-6783 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 368.4 |
| 分子式 | C21H18F2N2O2 |
| CAS号 | 1627709-94-7 |
| 稳定性 | ≥ 2 years |
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