CC-223
货号：
19917-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 19917-1mg |
| 描述 | CC-223 is a potent inhibitor of mTOR (IC50 = 16 nM) that shows selectivity for mTOR over a panel of 246 other kinases.1 It blocks signaling through both mTORC1 and mTORC2, inhibiting the phosphorylation of S6RP, 4EBP1, and Akt(S473) in cellular systems.1 CC-223 inhibits growth and induces apoptosis in hematologic and solid tumor cell lines in vitro, and it exhibits dose-dependent tumor growth inhibition in multiple solid tumor xenografts in vivo.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mortensen, D.S.,Fultz, K.E.,Xu, S., et al. CC-223, a potent and selective inhibitor of mTOR kinase: In vitro and in vivo characterization. Mol. Cancer Ther. 14(6), 1295-1305 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 397.5 |
| 分子式 | C21H27N5O3 |
| CAS号 | 1228013-30-6 |
| 稳定性 | ≥ 2 years |
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