AZD 3965
货号：
19912-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 19912-1mg |
| 描述 | AZD 3965 is a potent inhibitor of monocarboxylate transporter 1 (MCT1; Ki = 1.6 nM), killing tumor cells that are reliant on glycolysis by blocking lactate transport.1 It displays six-fold selectivity for MCT1 over MCT2 and is without effect against MCT4 at 10 µM. AZD 3965 increases intratumor lactate levels and decreases tumor growth in mice bearing COR-L103 small cell lung cancer (SCLC) xenografts.1 AZD 3965 also enhances radiosensitivity in mice with SCLC xenografts.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Polanski, R.,Hodgkinson, C.L.,Fusi, A., et al. Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer. Clin.Cancer.Res 20(4), (2014).
2.Bola, B.M.,Chadwick, A.L.,Michopoulos, F., et al. Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport. Mol.Cancer.Ther. 13(12), 2805-2816 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 515.5 |
| 分子式 | C21H24F3N5O5S |
| CAS号 | 1448671-31-5 |
| 稳定性 | ≥ 2 years |
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