| 货号 | 19704-5mg |
| 描述 | MRS2578 is an antagonist of the purinergic P2Y6 receptor (IC50s = 37 and 98 nM for human and rat receptors, respectively).1 It is without effect at other purinergic receptors. MRS2578 is used to study the cellular and physiological roles of P2Y6.2,3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mamedova, L.K.,Joshi, B.V.,Gao, Z.-G., et al. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem. Pharmacol. 67(9), 1763-1770 (2004). 2.Koizumi, S.,Shigemoto-Mogami, Y.,Nasu-Tada, K., et al. UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 446(78139), 1091-1095 (2007). 3.Kukulski, F.,Ben Yebdri, F.,Lefebvre, J., et al. Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo. J. Leukoc. Biol. 81(5), 1269-1275 (2007). 4.Ma, X.,Pan, X.,Wei, Y., et al. Chemotherapy-induced uridine diphosphate release promotes breast cancer metastasis through P2Y6 activation. Oncotarget 7(20), 29036-29050 (2016). 5.Sil, P.,Hayes, C.P.,Reaves, B.J., et al. P2Y6 receptor antagonist MRS2578 inhibits neutrophil activation and aggregated neutrophil extracellular trap formation induced by gout-associated monosodium urate crystals. J. Immunol. 198(1), 428-442 (2017). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 472.7 |
| 分子式 | C20H20N6S4 |
| CAS号 | 711019-86-2 |
| 稳定性 | ≥ 2 years |
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