| 货号 | 19455-500mg |
| 描述 | Clarithromycin is a macrolide antibiotic with effectiveness against pneumococci, Streptococcus,Listeria, and Corynebacterium.1,2 It also is used as part of a regimen to eradicate Helicobacter.3 Clarithromycin is a group 2 agent with respect to its interaction with the cytochrome P450 (CYP) isoform 3A4, as it exhibits a lower affinity for CYP3A4 than does erythromycin (Item No. 16486).4,5 |
| 别名 | A-56268;Antibiotic A 56268;TE 031; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hardy, D.J.,Hensey, D.M.,Beyer, J.M., et al. Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides. Antimicrobial Agents and Chemotherapy 32(11), 1710-1719 (1988). 2.Wilson, D.N. The A-Z of bacterial translation inhibitors. Crit. Rev. Biochem. Mol. Biol. 44(6), 393-433 (2009). 3.Li, B.Z.,Threapleton, D.E.,Wang, J.Y., et al. Comparative effectiveness and tolerance of treatments for Helicobacter pylori: Systematic review and network meta-analysis. BMJ 351, (2015). 4.Westphal, J.F. Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: An update focused on clarithromycin, azithromycin and dirithromycin. British Journal of Clinical Pharmacology 50(4), 285-295 (2000). 5.Williams, J.A.,Ring, B.J.,Cantrell, V.E., et al. Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metabolism and Disposition 30(8), 883-891 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 748 |
| 分子式 | C38H69NO13 |
| CAS号 | 81103-11-9 |
| 稳定性 | ≥ 2 years |
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