PF-4989216
货号：
19308-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 19308-1mg |
| 描述 | PF-4989216 is an orally bioavailable broad-spectrum PI3K inhibitor (IC50s = 2, 142, 65, 1, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively).1 It inhibits the cell viability of small-cell lung cancer (SCLC) cells with a mutation in PIK3CA, blocking PI3K downstream signaling and inducing apoptosis.1 PF-4989216 prevents tumor growth of SCLC cells harboring PIK3CA mutation in mice.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Walls, M.,Baxi, S.M.,Mehta, P.P., et al. Targeting small cell lung cancer harboring PIK3CA mutation with a selective oral PI3K inhibitor PF-4989216. Clin. Cancer Res. 20(3), 631-643 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 380.4 |
| 分子式 | C18H13FN6OS |
| CAS号 | 1276553-09-3 |
| 稳定性 | ≥ 2 years |
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