Diflunisal
货号：
19187-5g 基本售价：
490.0 元 规格：
5 g
产品信息
概述| 货号 | 19187-5g |
| 描述 | Diflunisal is a non-steroidal anti-inflammatory drug (NSAID) that inhibits both COX-1 (IC50 = 113 µM) and COX-2 (IC50s = 8.2 and 134 µM for human whole blood assay and human-modified whole blood assays, respectively).1 Peak plasma levels are achieved within two hours, with little metabolism before excretion in the urine.2 The terminal plasma half-life is approximately eight hours.2 |
| 别名 | 5-(2,4-Difluorophenyl)salicylic Acid;MK-647; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Warner, T.D.,Giuliano, F.,Vojnovic, I., et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proceedings of the National Academy of Sciences of the United States of America 96(13), 7563-7568 (1999).
2.Tempero, K.F.,Cirillo, V.J., and Steelman, S.L. Diflunisal: A review of pharmacokinetic and pharmacodynamic properties, drug interactions, and special tolerability studies in humans. British Journal of Clinical Pharmacology 4 Suppl 1, 31S-36S (1977).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 250.2 |
| 分子式 | C13H8F2O3 |
| CAS号 | 22494-42-4 |
| 稳定性 | ≥ 2 years |
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